There are three fibro drugs on the market: Cymbalta, Lyrica, and Savella. (Other drugs may be used off-label, meaning they aren’t specifically approved to treat fibro.)
Dizziness
One of the most common side effects of fibro drugs, reported by both doctors and patients, is dizziness.
Nausea
An upset stomach is one of the most common side effects of both Cymbalta and Savella, says Jacob Teitelbaum, MD, the medical director of the Fibromyalgia and Fatigue Centers, a nationwide chain of treatment centers.
Fatigue
About 22% of people who took Lyrica in a clinical trial experienced sleepiness (compared with 7% of those who took a placebo), and other fibro drugs can make you drowsy as well.
Dry mouth
Fibromyalgia is sometimes associated with an autoimmune disorder that zaps your ability to produce saliva (called Sjogren syndrome), and fibro meds can make that dry mouth even worse.
Interactions with other drugs
People with fibromyalgia may have other health problems as well, and about 70% take more than one medication regularly.
Hypertension
Cymbalta is a type of antidepressant known as a serotonin-norepinephrine reuptake inhibitor (SNRI).
Suicidal thoughts
All three of the drugs approved for fibromyalgia by the FDA have prominent warnings about a possible increase in suicidal thoughts or behavior.
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