It's long been thought that the two conditions are linked. People diagnosed with Alzheimer's disease may also have signs of heart disease, which has led researchers to wonder if treating cardiovascular symptoms might also prevent memory problems.
In the new study, published in the journal Acta Neuropathologica, an international team of researchers found new DNA points that seem to be involved in both cardiovascular disease and Alzheimer’s risk. The researchers analyzed differences in the DNA of patients with genetic factors that contribute to either condition and pinpointed 90 spots across the genome that seem to play a role in risk for both–six of which seemed particularly significant.
Then they dove deeper to confirm their findings by examining healthy adults. They found the same genetic risk factors in people with a family history of Alzheimer's who hadn't developed the condition themselves.
“These results imply that irrespective of what causes what, cardiovascular and Alzheimer’s pathology co-occur because they are linked genetically. That is, if you carry this handful of gene variants you may be at risk for not only heart disease but also Alzheimer’s,” study co-author Rahul S. Desikan, MD, PhD, an assistant professor of neuroradiology at the University of California San Francisco, said in a statement.
More research is needed for scientists to completely understand how to target the right genes to lower Alzheimer’s risk, but a first step may be managing cholesterol and triglycerides, they say.
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